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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730938
Species: Homo sapiens
CRRD Object: Gene
Symbol: PRKN
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:17963
Term: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Definition: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Chemical ID: MESH:D015632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDPRKN protein inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in decreased expression of TH]

PMID:25447324
decreases expressionISORGD:620896480464CTD1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in decreased expression of PRKN protein

PMID:23643664
decreases response to substanceISORGD:620896480464CTDPRKN protein results in decreased susceptibility to 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine

PMID:23643664
increases expressionISORGD:620896480464CTD1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased expression of PRKN mRNA, 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased expression of PRKN protein

PMID:22342763, PMID:27566062
multiple interactionsISORGD:620896480464CTDPRKN protein inhibits the reaction [PINK1 protein affects the susceptibility to 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine]

PMID:22511790
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.