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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730938
Species: Homo sapiens
CRRD Object: Gene
Symbol: PRKN
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDChlorpyrifos affects the localization of PRKN protein

PMID:26070385
multiple interactionsEXP 6480464CTDPRKN protein inhibits the reaction [Chlorpyrifos results in decreased expression of NDUFS3 protein], PRKN protein inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP3 protein], PRKN protein inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein modified form]

PMID:26070385
decreases expressionISORGD:620896480464CTDChlorpyrifos results in decreased expression of PRKN mRNA

PMID:29156651
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.