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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730938
Species: Homo sapiens
CRRD Object: Gene
Symbol: PRKN
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationISORGD:620896480464CTDAcetaminophen affects the localization of PRKN protein

PMID:25752611
decreases response to substanceISORGD:620896480464CTDPRKN gene mutant form results in decreased susceptibility to Acetaminophen

PMID:25752611
multiple interactionsISORGD:617976480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of PRKN mRNA

PMID:25607892
multiple interactionsISORGD:620896480464CTD[Acetaminophen co-treated with PRKN gene mutant form] results in decreased phosphorylation of GYS1 protein, Acetaminophen affects the reaction [PRKN gene mutant form affects the expression of CCND1 protein], Acetaminophen affects the reaction [PRKN gene mutant form affects the expression of PCNA protein], Acetaminophen affects the reaction [PRKN mutant form results in decreased expression of PCNA protein], Acetaminophen promotes the reaction [PRKN gene mutant form results in increased expression of MCL1 protein], PRKN gene mutant form affects the reaction [Acetaminophen results in increased phosphorylation of AKT1 protein], PRKN gene mutant form affects the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein], PRKN gene mutant form affects the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK9 protein], PRKN gene mutant form affects the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein], PRKN mutant form affects the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein], PRKN mutant form affects the reaction [Acetaminophen results in increased phosphorylation of MAPK9 protein], PRKN mutant form inhibits the reaction [Acetaminophen results in increased expression of MCL1 protein]

PMID:25752611
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.