GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | affects localization | ISO | RGD:62089 | 6480464 | CTD | Acetaminophen affects the localization of PRKN protein | PMID:25752611 | decreases response to substance | ISO | RGD:62089 | 6480464 | CTD | PRKN gene mutant form results in decreased susceptibility to Acetaminophen | PMID:25752611 | multiple interactions | ISO | RGD:61797 | 6480464 | CTD | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of PRKN mRNA | PMID:25607892 | multiple interactions | ISO | RGD:62089 | 6480464 | CTD | [Acetaminophen co-treated with PRKN gene mutant form] results in decreased phosphorylation of GYS1 protein, Acetaminophen affects the reaction [PRKN gene mutant form affects the expression of CCND1 protein], Acetaminophen affects the reaction [PRKN gene mutant form affects the expression of PCNA protein], Acetaminophen affects the reaction [PRKN mutant form results in decreased expression of PCNA protein], Acetaminophen promotes the reaction [PRKN gene mutant form results in increased expression of MCL1 protein], PRKN gene mutant form affects the reaction [Acetaminophen results in increased phosphorylation of AKT1 protein], PRKN gene mutant form affects the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein], PRKN gene mutant form affects the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK9 protein], PRKN gene mutant form affects the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein], PRKN mutant form affects the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein], PRKN mutant form affects the reaction [Acetaminophen results in increased phosphorylation of MAPK9 protein], PRKN mutant form inhibits the reaction [Acetaminophen results in increased expression of MCL1 protein] | PMID:25752611 | | ||||||||||||||||||||||
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