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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730938
Species: Homo sapiens
CRRD Object: Gene
Symbol: PRKN
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:617976480464CTDKetoconazole results in increased expression of PRKN mRNA, Ketoconazole results in increased expression of PRKN protein

PMID:25787151
increases response to substanceISORGD:617976480464CTDPRKN protein results in increased susceptibility to Ketoconazole

PMID:25787151
multiple interactionsISORGD:617976480464CTD1, 2-Dihydroxybenzene-3, 5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA], 1, 2-Dihydroxybenzene-3, 5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN protein], tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA], tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN protein]

PMID:25787151
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.