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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730938
Species: Homo sapiens
CRRD Object: Gene
Symbol: PRKN
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:78741
Term: oxidopamine
Definition: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chemical ID: MESH:D016627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDOxidopamine affects the expression of PRKN protein alternative form

PMID:28688199
decreases expressionEXP 6480464CTDOxidopamine results in decreased expression of PRKN protein

PMID:28688199, PMID:30707903
decreases reactionEXP 6480464CTDPRKN protein inhibits the reaction Oxidopamine

PMID:15198987
multiple interactionsEXP 6480464CTDPINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]], salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein], Tretinoin affects the reaction [Oxidopamine affects the expression of PRKN protein alternative form]

PMID:28688199, PMID:30707903
increases expressionISORGD:617976480464CTDOxidopamine results in increased expression of PRKN mRNA

PMID:25129099
multiple interactionsISORGD:617976480464CTDisoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA], Levodopa inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA], Rutin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]

PMID:25129099
multiple interactionsISORGD:620896480464CTDPRKN protein inhibits the reaction [Oxidopamine results in decreased expression of TH protein]

PMID:16914382
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.