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CRRD ID: 730938
Species: Homo sapiens
CRRD Object: Gene
Symbol: PRKN
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: GO:0061630
Term: ubiquitin protein ligase activity
Definition: Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
Definition Source(s): GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAFB:FBgn0017418, FB:FBgn0041100, MGI:MGI:1355296, PANTHER:PTN000188395, TAIR:locus:2057401, UniProtKB:O60260, UniProtKB:P50876, UniProtKB:Q6ZMZ02290271GO_Central (PMID:21873635)

 IDA 2290271ParkinsonsUK-UCL (PMID:10973942), (PMID:11439185), (PMID:12150907), (PMID:12628165), (PMID:12925569), (PMID:16227987), (PMID:19229105), (PMID:19880420), (PMID:20823226), (PMID:21376232), (PMID:23858059), (PMID:25621951)

PMID:10973942, PMID:11439185, PMID:12150907, PMID:12628165, PMID:12925569, PMID:16227987, PMID:19229105, PMID:19880420, PMID:20823226, PMID:21376232, PMID:23858059, PMID:25621951
 NAS 2290271ParkinsonsUK-UCL (PMID:10973942), (PMID:18221368)

PMID:10973942, PMID:18221368
 TAS 2290271Reactome Reactome:R-HSA-5689111
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.