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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 732487
Species: Homo sapiens
CRRD Object: Gene
Symbol: TGM2
Name: transglutaminase 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7324886480464CTDDexamethasone results in increased expression of TGM2 mRNA

PMID:23946490, PMID:29229235
multiple interactionsISORGD:7324886480464CTDapicidin inhibits the reaction [Dexamethasone results in increased expression of TGM2 mRNA], trichostatin A inhibits the reaction [Dexamethasone results in increased expression of TGM2 mRNA], Valproic Acid inhibits the reaction [Dexamethasone results in increased expression of TGM2 mRNA]

PMID:23946490
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.