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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 732487
Species: Homo sapiens
CRRD Object: Gene
Symbol: TGM2
Name: transglutaminase 2
Acc ID: CHEBI:50648
Term: 9-cis-retinoic acid
Definition: A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.
Chemical ID: MESH:C103303
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDAlitretinoin results in increased activity of TGM2 protein

PMID:9516142
increases expressionEXP 6480464CTDAlitretinoin results in increased expression of TGM2 mRNA, Alitretinoin results in increased expression of TGM2 protein

PMID:15964820, PMID:16158052, PMID:17034753, PMID:9516142
multiple interactionsEXP 6480464CTD[Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H3-4 protein modified form binds to TGM2 gene], [Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H4-16 protein modified form binds to TGM2 gene], Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA], Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 protein], periodate-oxidized adenosine inhibits the reaction [Alitretinoin results in increased expression of TGM2 mRNA], periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA]], Vitamin D promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA]

PMID:15964820
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.