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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 732487
Species: Homo sapiens
CRRD Object: Gene
Symbol: TGM2
Name: transglutaminase 2
Acc ID: CHEBI:75261
Term: arotinoid acid
Definition: A retinoid that consists of benzoic acid substituted at position 4 by a 2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl group. It is a synthetic retinoid that acts as a selective agonist for the retinoic acid receptors (RAR).
Chemical ID: MESH:C038864
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTD4-(2-(5, 6, 7, 8-tetrahydro-5, 5, 8, 8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of TGM2 mRNA, 4-(2-(5, 6, 7, 8-tetrahydro-5, 5, 8, 8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of TGM2 protein

PMID:10910994, PMID:16158052
multiple interactionsEXP 6480464CTDTetrachlorodibenzodioxin inhibits the reaction [4-(2-(5, 6, 7, 8-tetrahydro-5, 5, 8, 8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of TGM2 mRNA]

PMID:10910994
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