Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733705
Species: Homo sapiens
CRRD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDToluene 2, 4-Diisocyanate analog affects the localization of CTNNB1 protein

PMID:30261222
multiple interactionsEXP 6480464CTDAG 1879 inhibits the reaction [Toluene 2, 4-Diisocyanate analog affects the localization of CTNNB1 protein], AGER protein affects the reaction [Toluene 2, 4-Diisocyanate analog affects the localization of CTNNB1 protein], CAV1 protein mutant form inhibits the reaction [Toluene 2, 4-Diisocyanate analog affects the localization of CTNNB1 protein], FPS-ZM1 inhibits the reaction [Toluene 2, 4-Diisocyanate analog affects the localization of CTNNB1 protein]

PMID:30261222
affects localizationISORGD:15504666480464CTDToluene 2, 4-Diisocyanate affects the localization of CTNNB1 protein

PMID:30261222
increases phosphorylationISORGD:15504666480464CTDToluene 2, 4-Diisocyanate results in increased phosphorylation of CTNNB1 protein

PMID:26089345
multiple interactionsISORGD:15504666480464CTD2-(1, 3-dimethyl-2, 6-dioxo-1, 2, 3, 6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2, 4-Diisocyanate results in decreased expression of and affects the localization of CTNNB1 protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased phosphorylation of CTNNB1 protein], AG 1879 inhibits the reaction [Toluene 2, 4-Diisocyanate affects the localization of CTNNB1 protein], FPS-ZM1 inhibits the reaction [Toluene 2, 4-Diisocyanate affects the localization of CTNNB1 protein], GSK2193874 inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein], Toluene 2, 4-Diisocyanate results in decreased expression of and affects the localization of CTNNB1 protein, Toluene 2, 4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein

PMID:26089345, PMID:30261222, PMID:30517707
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.