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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733705
Species: Homo sapiens
CRRD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:6541
Term: losartan
Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Chemical ID: MESH:D019808
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDLosartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein], Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein], Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]

PMID:28578904
multiple interactionsISORGD:15504666480464CTDLosartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein], Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA], Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]

PMID:28578904
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.