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CRRD ID: 736906
Species: Homo sapiens
CRRD Object: Gene
Symbol: HRG
Name: histidine rich glycoprotein
Acc ID: GO:0062023
Term: collagen-containing extracellular matrix
Definition: An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
Definition Source(s): GOC:BHF, GOC:rph, PMID:21123617
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 HDA 2290271BHF-UCL (PMID:25037231), (PMID:28344315), (PMID:28675934)

PMID:25037231, PMID:28344315, PMID:28675934
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.