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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737062
Species: Homo sapiens
CRRD Object: Gene
Symbol: PRKCA
Name: protein kinase C alpha
Acc ID: CHEBI:15738
Term: staurosporine
Definition: An indolocarbazole alkaloid that has formula C28H26N4O3.
Chemical ID: MESH:D019311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDStaurosporine affects the localization of and affects the activity of PRKCA protein

PMID:16225760
multiple interactionsISORGD:33956480464CTD[linsidomine co-treated with Staurosporine] results in decreased expression of PRKCA protein, Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCA protein], Staurosporine inhibits the reaction [linsidomine results in increased phosphorylation of PRKCA protein], Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]

PMID:11994256, PMID:14678745
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.