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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737062
Species: Homo sapiens
CRRD Object: Gene
Symbol: PRKCA
Name: protein kinase C alpha
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7370636480464CTDDizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]], HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]], Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]

PMID:18652891
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.