Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737411
Species: Homo sapiens
CRRD Object: Gene
Symbol: AQP8
Name: aquaporin 8
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7374126480464CTDTetrachlorodibenzodioxin affects the expression of AQP8 mRNA

PMID:21570461, PMID:26377647
decreases expressionISORGD:7374126480464CTDTetrachlorodibenzodioxin results in decreased expression of AQP8 mRNA

PMID:28213091, PMID:28922406
multiple interactionsISORGD:7374126480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AQP8 mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of AQP8 mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to AQP8 gene]

PMID:17942748, PMID:25975270, PMID:28213091
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.