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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737414
Species: Mus musculus
CRRD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:164200
Term: triclosan
Definition: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Chemical ID: MESH:D014260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7374136480464CTDTriclosan results in decreased expression of CDH1 protein

PMID:28844962
increases expressionISORGD:7374136480464CTDTriclosan results in increased expression of CDH1 mRNA

PMID:30510588
multiple interactionsISORGD:7374136480464CTD3, 3'-diindolylmethane inhibits the reaction [Triclosan results in decreased expression of CDH1 protein], fulvestrant inhibits the reaction [Triclosan results in decreased expression of CDH1 protein], plerixafor octahydrochloride inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]

PMID:28844962
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.