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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737414
Species: Mus musculus
CRRD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:28088
Term: genistein
Definition: 7-Hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDGenistein results in decreased expression of CDH1 mRNA

PMID:21048042
increases expressionISORGD:692796480464CTDGenistein results in increased expression of CDH1 protein

PMID:17166883
increases expressionISORGD:7374136480464CTDGenistein results in increased expression of CDH1

PMID:29899271
multiple interactionsISORGD:7374136480464CTDGenistein inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein], Genistein inhibits the reaction [Estradiol results in decreased expression of CDH1 protein], Genistein inhibits the reaction [nonylphenol results in decreased expression of CDH1 protein]

PMID:26407941
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.