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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737414
Species: Mus musculus
CRRD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7374136480464CTDfulvestrant inhibits the reaction [2, 4-dihydroxybenzophenone results in decreased expression of CDH1 protein], fulvestrant inhibits the reaction [3, 4, 5, 3', 4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA], fulvestrant inhibits the reaction [4-tert-octylphenol results in decreased expression of CDH1 protein], fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein], fulvestrant inhibits the reaction [afimoxifene results in increased expression of CDH1 protein], fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CDH1 protein], fulvestrant inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein], fulvestrant inhibits the reaction [bisphenol A results in increased expression of CDH1 protein], fulvestrant inhibits the reaction [bisphenol F results in increased expression of CDH1 protein], fulvestrant inhibits the reaction [Estradiol results in decreased expression of CDH1 protein], fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDH1 protein], fulvestrant inhibits the reaction [nonylphenol results in decreased expression of CDH1 protein], fulvestrant inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]

PMID:19593637, PMID:25690688, PMID:26407941, PMID:27145024, PMID:27539251, PMID:28284859, PMID:28808208, PMID:28844962
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.