Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - TERM ANNOTATION REPORT

CRRD ID: 737494
Species: Homo sapiens
CRRD Object: Gene
Symbol: SYP
Name: synaptophysin
Acc ID: DOID:10652
Term: Alzheimer's disease
Definition: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Definition Source(s): MESH:D000544, http://en.wikipedia.org/wiki/Alzheimer%27s_disease, http://www.merriam-webster.com/medical/alzheimer%27s%20disease, http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IEP 13506238CRRDprotein:decreased expression:dentate gyrus molecular layer, hippocampus, entorhinal, tempocampal corteces:

 
 ISORGD:1137313506238CRRDdenntate gyrus, hippocampus, entorhinal cortex

 
 ISORGD:380213506238CRRDmRNA, protein:decreased expression:hippocampus, temporal cortex

 
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.