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GENE - TERM ANNOTATION REPORT

CRRD ID: 8713810
Species: Chinchilla lanigera
CRRD Object: Gene
Symbol: Dcx
Name: doublecortin
Acc ID: DOID:0050453
Term: lissencephaly
Definition: A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.
Definition Source(s): MESH:D054082, http://en.wikipedia.org/wiki/Lissencephaly, http://www.ninds.nih.gov/disorders/lissencephaly/lissencephaly.htm
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISSRGD:13486379068941MouseDOOMIM:300067 , OMIM:300215 , OMIM:607432 , OMIM:611603 , OMIM:614019 , OMIM:615191

 
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.