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GENE - TERM ANNOTATION REPORT

CRRD ID: 8877326
Species: Chinchilla lanigera
CRRD Object: Gene
Symbol: Runx3
Name: RUNX family transcription factor 3
Acc ID: PW:0000490
Term: transforming growth factor-beta Smad dependent signaling pathway
Definition: Transforming growth factor-beta (TGF-beta) signaling is one of the best characterized module of the Tgf-b superfamily pathways. Binding to the type II receptor leads to activation of the type I receptor and subsequent activation of Smad pathway. Nuclear translocation of Smad(s) and interaction with transcription factors leads to activation or repression of many genes.
Definition Source(s): PMID:16678165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.