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CRRD ID: 8903363
Species: Chinchilla lanigera
CRRD Object: Gene
Symbol: Fzd4
Name: frizzled class receptor 4
Acc ID: GO:0060070
Term: canonical Wnt signaling pathway
Definition: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Definition Source(s): GOC:bf, GOC:dph, PMID:11532397, PMID:19619488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISSRGD:118154469068941ARUK-UCL PMID:25424568
 ISSRGD:118154469068941BHF-UCL PMID:14688793, PMID:20802536, PMID:28733458
 ISSRGD:118154469068941GO_Central PMID:21873635
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.