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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2460
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:116509
Term: diuron
Definition: A member of the class of phenylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group.
Chemical ID: MESH:D004237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDDiuron results in decreased expression of CYP1B1 mRNA

PMID:25152437
increases expressionEXP 6480464CTDDiuron results in increased expression of CYP1B1 mRNA

PMID:21551480
increases expressionISOCRRD:7367656480464CTDDiuron metabolite results in increased expression of CYP1B1 mRNA

PMID:24172598
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