GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 6499724
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tcim
Name: transcriptional and immune response regulator
Acc ID: CHEBI:132082
Term: entinostat
Definition: A member of the class of benzamides resulting from the formal condensation of the carboxy group of the pyridin-3-ylmethyl carbamate derivative of p-(aminomethyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an inhibitor of histone deacetylase isoform 1 (HDAC1) and isoform 3 (HDAC3).
Chemical ID: MESH:C118739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:13462796480464CTDentinostat results in decreased expression of TCIM mRNA

PMID:26272509
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.