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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1309970
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gsta4
Name: glutathione S-transferase alpha 4
Acc ID: CHEBI:133920
Term: N-hydroxy-PhIP
Definition: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP.
Chemical ID: MESH:C060533
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTD2-hydroxyamino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of GSTA4 protein

PMID:17122891
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.