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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 628831
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:135849
Term: manidipine
Definition: null
Chemical ID: MESH:C054218
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:7341036480464CTDmanidipine results in increased activity of NR1H4 protein

PMID:25257666
multiple interactionsISORGD:7341036480464CTDmanidipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein], manidipine inhibits the reaction [pregna-4, 17-diene-3, 16-dione results in decreased activity of NR1H4 protein]

PMID:25257666
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.