GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3718
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Slc9a1
Name: solute carrier family 9 member A1
Acc ID: CHEBI:136538
Term: ethylisopropylamiloride
Definition: A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.
Chemical ID: MESH:C039614
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDethylisopropylamiloride results in decreased activity of SLC9A1 protein

PMID:17552965
decreases activityISOCRRD:7365856480464CTDethylisopropylamiloride results in decreased activity of SLC9A1 protein

PMID:12562776
multiple interactionsISOCRRD:7365856480464CTD[ethylisopropylamiloride results in decreased activity of SLC9A1 protein] which results in increased abundance of Doxorubicin

PMID:15729714
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.