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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2460
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:136666
Term: eupatorin
Definition: A trimethoxyflavone that is 6-hydroxyluteolin in which the phenolic hydogens at positions 4', 6 and 7 have been replaced by methyl groups.
Chemical ID: MESH:C103110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISOCRRD:7367656480464CTDeupatorin results in decreased activity of CYP1B1 protein

PMID:21482471
increases expressionISOCRRD:7367656480464CTDeupatorin results in increased expression of CYP1B1 mRNA

PMID:19601638
increases metabolic processingISOCRRD:7367656480464CTDCYP1B1 protein results in increased metabolism of eupatorin analog

PMID:21482471
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.