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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1316165
Species: Mus musculus
CRRD Object: Gene
Symbol: Ppp6r3
Name: protein phosphatase 6, regulatory subunit 3
Acc ID: CHEBI:1391
Term: 3,4-methylenedioxymethamphetamine
Definition: A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Chemical ID: MESH:D018817
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp6r3decreases methylationEXP 6480464CTDN-Methyl-3, 4-methylenedioxyamphetamine results in decreased methylation of SAPS3 promoter

PMID:26251327
Ppp6r3increases expressionEXP 6480464CTDN-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of PPP6R3 mRNA, N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of SAPS3 mRNA

PMID:20188158, PMID:26251327
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.