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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1587989
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sin3b
Name: SIN3 transcription regulator family member B
Acc ID: CHEBI:1391
Term: 3,4-methylenedioxymethamphetamine
Definition: A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
Chemical ID: MESH:D018817
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:16168276480464CTDN-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of SIN3B mRNA

PMID:26251327
increases methylationISORGD:16168276480464CTDN-Methyl-3, 4-methylenedioxyamphetamine results in increased methylation of SIN3B promoter

PMID:26251327
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.