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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3952
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:114816480464CTD5-(3-methoxy-5-(4-methoxystyryl)phenoxy)-2,2-dimethylpentanoic acid analog inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of VCAM1 mRNA]

5-(3-methoxy-5-(4-methoxystyryl)phenoxy)-2,2-dimethylpentanoic acid analog inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of VCAM1 protein]

[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of VCAM1 mRNA

[Methionine deficiency co-treated with Choline deficiency] results in increased expression of VCAM1 mRNA

[Methionine deficiency co-treated with Choline deficiency] results in increased expression of VCAM1 protein

alisol B 23-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of VCAM1 mRNA]

Chenodeoxycholic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of VCAM1 mRNA]

PMID:20938992, PMID:27773935, PMID:30745416
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.