GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1310517
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tgif1
Name: TGFB-induced factor homeobox 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:13214636480464CTDTretinoin results in decreased expression of TGIF1 mRNA

PMID:15498508
increases response to substanceISOCRRD:13214646480464CTDTGIF1 gene mutant form results in increased susceptibility to Tretinoin

PMID:16428452
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.