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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2456
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTretinoin results in decreased expression of CYP17A1 mRNA

PMID:14960491
increases expressionISOCRRD:13505406480464CTDTretinoin results in increased expression of CYP17A1 mRNA

PMID:16621909
multiple interactionsISOCRRD:7372226480464CTDTretinoin inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]

PMID:22285649
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