GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3771
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:7321846480464CTDTretinoin results in decreased expression of STAT1 protein

PMID:16007204
increases expressionISOCRRD:7321846480464CTDTretinoin results in increased expression of STAT1 mRNA

PMID:16140955, PMID:20945414
multiple interactionsISOCRRD:7321846480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in increased expression of and results in increased phosphorylation of STAT1 protein]

benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in increased expression of STAT1 mRNA]

Ro 41-5253 inhibits the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein]

STAT1 protein affects the reaction [Tretinoin results in increased expression of CEBPE protein]

STAT1 protein affects the reaction [Tretinoin results in increased expression of IRF8 protein]

STAT1 protein affects the reaction [Tretinoin results in increased expression of STAT2 protein]

STAT1 protein promotes the reaction [Tretinoin results in increased expression of CLIP1 mRNA]

Thiophenes analog promotes the reaction [Tretinoin results in increased expression of STAT1 mRNA]

Tretinoin inhibits the reaction [IFNG protein results in increased expression of STAT1 protein]

Tretinoin inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]

Tretinoin promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]

Tretinoin results in increased expression of and results in increased phosphorylation of STAT1 protein

Tretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein

PMID:16007204, PMID:16085646, PMID:16140955, PMID:16574066, PMID:16636311, PMID:16918696, PMID:20945414
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.