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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDTretinoin results in increased expression of NR0B2 mRNA

PMID:21274875
affects metabolic processingISORGD:7328746480464CTDNR0B2 protein affects the metabolism of Tretinoin

PMID:17289919
increases expressionISORGD:7328736480464CTDTretinoin results in increased expression of NR0B2 mRNA, Tretinoin results in increased expression of NR0B2 protein

PMID:21274875, PMID:30709899
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.