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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 732569
Species: Homo sapiens
CRRD Object: Gene
Symbol: MFN2
Name: mitofusin 2
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:6288436480464CTDOxygen deficiency results in decreased expression of MFN2 mRNA, Oxygen deficiency results in decreased expression of MFN2 protein

PMID:26593335, PMID:27684054, PMID:28478070
multiple interactionsISORGD:6288436480464CTD[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of MFN2 mRNA, [Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of MFN2 protein, [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MFN2 mRNA, [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MFN2 protein, Atorvastatin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of MFN2 protein], breviscapine inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MFN2 mRNA], breviscapine inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MFN2 protein], epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 mRNA], epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 protein], ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 mRNA], ginsenoside Rg1 inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 protein], KLF4 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 mRNA]], KLF4 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 protein]], MFN2 protein inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased chemical synthesis of Adenosine Triphosphate], MFN2 protein inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased chemical synthesis of Reactive Oxygen Species], MFN2 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]], MFN2 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]], Oxygen deficiency inhibits the reaction [Glucose results in increased expression of MFN2 protein], Rosiglitazone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of MFN2 mRNA], Rosiglitazone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of MFN2 protein], Sevoflurane inhibits the reaction [Oxygen deficiency inhibits the reaction [Glucose results in increased expression of MFN2 protein]], Sevoflurane inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 protein]

PMID:24721408, PMID:24898700, PMID:26593335, PMID:27363631, PMID:27684054, PMID:28478070
multiple interactionsISORGD:7325706480464CTD[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of MFN2 protein, genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of MFN2 protein]

PMID:28477916
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.