Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621612
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nts
Name: neurotensin
Acc ID: CHEBI:15738
Term: staurosporine
Definition: An indolocarbazole alkaloid that has formula C28H26N4O3.
Chemical ID: MESH:D019311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:13190926480464CTDStaurosporine results in increased activity of NTS protein

PMID:18313772
multiple interactionsISORGD:13190926480464CTDStaurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein], Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein], Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein], Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein], Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein], Staurosporine promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates], Tetradecanoylphorbol Acetate inhibits the reaction [Staurosporine results in increased activity of NTS protein]

PMID:15177934, PMID:18313772
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.