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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621246
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Top1
Name: DNA topoisomerase I
Acc ID: CHEBI:15864
Term: luteolin
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4' 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an inflammatory agent and an immune system modulator as well as being active against several cancers.
Chemical ID: MESH:D047311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDLuteolin binds to and results in decreased activity of TOP1 protein

PMID:12027807
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