GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2456
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDAtrazine results in decreased expression of CYP17A1 mRNA

PMID:19541795
increases expressionEXP 6480464CTDAtrazine results in increased expression of CYP17A1 mRNA

Atrazine results in increased expression of CYP17A1 protein

PMID:20667998, PMID:23200735
multiple interactionsEXP 6480464CTD[Atrazine co-treated with Bucladesine] results in increased expression of CYP17A1 mRNA

Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of CYP17A1 mRNA]

Quercetin inhibits the reaction [Atrazine results in increased expression of CYP17A1 mRNA]

PMID:23200735
decreases expressionISOCRRD:7372226480464CTDAtrazine results in decreased expression of CYP17A1 mRNA

PMID:23376530, PMID:23591565
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.