Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1307751
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Srebf2
Name: sterol regulatory element binding transcription factor 2
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein, Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein]

PMID:20578043
multiple interactionsISORGD:7309726480464CTD[25-hydroxycholesterol co-treated with Cholesterol] results in decreased cleavage of SREBF2 protein, [[Troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased abundance of Cholesterol, SREBF2 promotes the reaction [bisphenol A results in increased import of Cholesterol]

PMID:16946405, PMID:27324795, PMID:28057006
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.