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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1359298
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Clec4e
Name: C-type lectin domain family 4, member E
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases response to substanceISORGD:13440506480464CTDCLEC4E protein results in increased susceptibility to Cholesterol

PMID:26296894
multiple interactionsISORGD:13440506480464CTD[Cholesterol co-treated with CLEC4E] results in increased expression of CXCL2 protein, [Cholesterol co-treated with CLEC4E] results in increased expression of TNF protein, Cholesterol binds to and results in increased activity of CLEC4E protein, CLEC4E protein inhibits the reaction [Cholesterol results in increased expression of TIMP3 mRNA], CLEC4E protein promotes the reaction [[Cholesterol co-treated with Lipopolysaccharides] results in increased expression of IL1B protein], CLEC4E protein promotes the reaction [Cholesterol results in increased expression of AREG mRNA], CLEC4E protein promotes the reaction [Cholesterol results in increased expression of CCL4 mRNA], CLEC4E protein promotes the reaction [Cholesterol results in increased expression of CLEC5A mRNA], CLEC4E protein promotes the reaction [Cholesterol results in increased expression of CSF1 mRNA], CLEC4E protein promotes the reaction [Cholesterol results in increased expression of DCSTAMP mRNA]

PMID:26296894
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.