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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2835
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDEthanol affects the expression of HSD11B2 mRNA

PMID:31039417
decreases expressionEXP 6480464CTDEthanol results in decreased expression of HSD11B2 mRNA, Ethanol results in decreased expression of HSD11B2 protein

PMID:29802914
decreases expressionISORGD:7374686480464CTDEthanol results in decreased expression of HSD11B2 mRNA, Ethanol results in decreased expression of HSD11B2 protein

PMID:29802914
multiple interactionsISORGD:7374686480464CTDColforsin inhibits the reaction [Ethanol results in decreased expression of HSD11B2 mRNA], Colforsin inhibits the reaction [Ethanol results in decreased expression of HSD11B2 protein], EGR1 protein promotes the reaction [Ethanol results in decreased expression of HSD11B2 mRNA], EGR1 protein promotes the reaction [Ethanol results in decreased expression of HSD11B2 protein], Ethanol inhibits the reaction [Colforsin results in increased expression of HSD11B2 mRNA], Ethanol inhibits the reaction [Colforsin results in increased expression of HSD11B2 protein], Ethanol promotes the reaction [EGR1 protein results in decreased expression of HSD11B2 mRNA], Ethanol promotes the reaction [EGR1 protein results in decreased expression of HSD11B2 protein]

PMID:29802914
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.