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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDEthanol results in increased expression of TIMP2 protein

PMID:12524413, PMID:21172400
multiple interactionsEXP 6480464CTDbetulin inhibits the reaction [Ethanol results in increased expression of TIMP2 protein], betulinic acid inhibits the reaction [Ethanol results in increased expression of TIMP2 protein]

PMID:21172400
affects splicingISORGD:621786480464CTDEthanol affects the splicing of TIMP2 mRNA

PMID:30319688
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.