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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730973
Species: Mus musculus
CRRD Object: Gene
Symbol: Srebf2
Name: sterol regulatory element binding factor 2
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases cleavageEXP 6480464CTDHydrogen Peroxide results in increased cleavage of SREBF2 protein

PMID:29499335
multiple interactionsEXP 6480464CTDButhionine Sulfoximine inhibits the reaction [Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein]], Buthionine Sulfoximine promotes the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein], dorsomorphin promotes the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein], Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein]

PMID:29499335
multiple interactionsISORGD:7309726480464CTD[isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 protein, [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of SREBF2 mRNA, SREBF2 protein affects the susceptibility to [isoquercitrin co-treated with Hydrogen Peroxide]

PMID:18032389
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.