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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619573
Species: Mus musculus
CRRD Object: Gene
Symbol: Slc22a6
Name: solute carrier family 22 (organic anion transporter), member 6
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a6multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA], Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]

PMID:21909718
Slc22a6affects expressionISORGD:693386480464CTDQuercetin affects the expression of SLC22A6 protein

PMID:24958931
Slc22a6multiple interactionsISORGD:6195726480464CTDQuercetin inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog], Quercetin inhibits the reaction [SLC22A6 protein results in increased susceptibility to N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2, 6-diaminopurine], Quercetin inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]

PMID:19605544, PMID:23856525
Slc22a6multiple interactionsISORGD:693386480464CTDQuercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA], Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]

PMID:19605544
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.