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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620029
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7327526480464CTDQuercetin results in decreased expression of NR4A1 mRNA

PMID:25862958
increases expressionISORGD:7327516480464CTDQuercetin results in increased expression of NR4A1 mRNA

PMID:21632981
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.