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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceEXP 6480464CTDEGFR protein affects the susceptibility to Quercetin

PMID:12168845
decreases expressionEXP 6480464CTDQuercetin results in decreased expression of EGFR mRNA

PMID:21308698
decreases phosphorylationEXP 6480464CTDQuercetin results in decreased phosphorylation of EGFR protein

PMID:18618485, PMID:21308698, PMID:21756928, PMID:21967610, PMID:23099361
multiple interactionsEXP 6480464CTD[Cisplatin co-treated with Quercetin] results in increased expression of EGFR mRNA, EGF protein inhibits the reaction [Quercetin results in decreased phosphorylation of EGFR protein], Quercetin affects the activity of and results in decreased phosphorylation of EGFR protein, Quercetin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein], Quercetin inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein], Quercetin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], Quercetin results in decreased phosphorylation of and results in increased activity of EGFR protein

PMID:10556937, PMID:12168845, PMID:15135307, PMID:21756928, PMID:27514524
multiple interactionsISORGD:105116480464CTDQuercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EGFR protein]

PMID:23099361
multiple interactionsISORGD:25436480464CTDQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of EGFR protein]

PMID:25164625
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.