Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceEXP 6480464CTDEGFR protein affects the susceptibility to Quercetin

PMID:12168845
decreases expressionEXP 6480464CTDQuercetin results in decreased expression of EGFR mRNA

PMID:21308698
decreases phosphorylationEXP 6480464CTDQuercetin results in decreased phosphorylation of EGFR protein

PMID:18618485, PMID:21308698, PMID:21756928, PMID:21967610, PMID:23099361
multiple interactionsEXP 6480464CTD[Cisplatin co-treated with Quercetin] results in increased expression of EGFR mRNA, EGF protein inhibits the reaction [Quercetin results in decreased phosphorylation of EGFR protein], Quercetin affects the activity of and results in decreased phosphorylation of EGFR protein, Quercetin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein], Quercetin inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein], Quercetin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], Quercetin results in decreased phosphorylation of and results in increased activity of EGFR protein

PMID:10556937, PMID:12168845, PMID:15135307, PMID:21756928, PMID:27514524
multiple interactionsISORGD:105116480464CTDQuercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EGFR protein]

PMID:23099361
multiple interactionsISORGD:25436480464CTDQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of EGFR protein]

PMID:25164625
Go Back to source page   Continue to Ontology report

Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.