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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1597139
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Idh2
Name: isocitrate dehydrogenase (NADP(+)) 2
Acc ID: CHEBI:16244
Term: 4-(trimethylammonio)butanoate
Definition: An amino-acid betaine gamma-aminobutyric acid zwitterion in which all of the hydrogens attached to the nitrogen are replaced by methyl groups.
Chemical ID: MESH:C002889
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Idh2increases abundanceISORGD:15573556480464CTDIDH2 protein mutant form results in increased abundance of gamma-butyrobetaine

PMID:27469509
Idh2multiple interactionsISORGD:15573556480464CTDTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of gamma-butyrobetaine]

PMID:27469509
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.