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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDLithocholic Acid results in increased expression of NR0B2 mRNA

PMID:20888898
multiple interactionsEXP 6480464CTD[Lithocholic Acid binds to VDR protein] which results in increased expression of NR0B2 mRNA

PMID:19562681
decreases expressionISORGD:7328746480464CTDLithocholic Acid results in decreased expression of NR0B2 mRNA

PMID:20359477
increases expressionISORGD:7328736480464CTDLithocholic Acid results in increased expression of NR0B2 mRNA, Lithocholic Acid results in increased expression of NR0B2 protein

PMID:19562681, PMID:22540009, PMID:25055961, PMID:30419252
increases expressionISORGD:7328746480464CTDLithocholic Acid results in increased expression of NR0B2 mRNA

PMID:22982774, PMID:25582706
multiple interactionsISORGD:7328736480464CTD[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA, [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA

PMID:17963371
multiple interactionsISORGD:7328746480464CTD[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of NR0B2 mRNA

PMID:20359477
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.