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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70913
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Abcc5
Name: ATP binding cassette subfamily C member 5
Acc ID: CHEBI:16336
Term: hyaluronic acid
Definition: A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.
Chemical ID: MESH:D006820
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases exportISORGD:7343636480464CTDABCC5 protein results in increased export of Hyaluronic Acid

PMID:23978416
multiple interactionsISORGD:7343636480464CTD[Curcumin analog binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid, [Curcumin binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid, [xanthohumol binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid, Curcumin analog inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid], Curcumin inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid], xanthohumol inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]

PMID:23978416
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.